Tuberculosis

• Mycobacterium tuberculosis infection

• Inhalation of droplets → granuloma formation → latent or active disease

• Chronic cough, hemoptysis
• Night sweats, weight loss, fever
• Fatigue, malaise

• Acid-fast bacilli (AFB) in sputum
• CXR: upper lobe infiltrates, cavitation
• Positive Mantoux/IGRA test

• RIPE therapy: Rifampin, Isoniazid, Pyrazinamide, Ethambutol
• Directly observed therapy (DOT) recommended