NEPHROLOGY
Rapidly Progressive Glomerulonephritis (RPGN)
Etiology
• Goodpasture syndrome (anti-GBM)
• Granulomatosis with polyangiitis (ANCA)
• Post-infectious or idiopathic
Pathogenesis
• Crescent formation → rapid loss of renal function
Clinical features
• Rapid onset oliguria/anuria
• Hematuria, proteinuria
• Fatigue, edema
Lab findings
• ↑ Serum creatinine, ↑ BUN
• RBC casts
• Serology: anti-GBM, ANCA
Treatment
• High-dose steroids + cyclophosphamide
• Plasmapheresis for anti-GBM