NEUROLOGY
Etiology
Age-related
Genetic (APOE-ε4)
Amyloid precursor protein mutations
Pathogenesis
β-amyloid plaques
Neurofibrillary tangles (tau)
Progressive cortical atrophy
Clinical Features
Memory impairment
Disorientation
Personality changes
Executive dysfunction
Later: aphasia, apraxia, agnosia
Treatment
Cholinesterase inhibitors (donepezil)
NMDA antagonist (memantine)
Supportive care, caregiver support