GASTROENTEROLOGY
Etiology
Age, family history
Adenoma-carcinoma sequence
IBD (UC > Crohn’s)
Genetic syndromes (FAP, Lynch)
Pathogenesis
Progressive mutation accumulation → polyp → carcinoma
Diagnosis
Colonoscopy (gold standard)
CT colonography
CEA for monitoring
Treatment
Surgical resection
Chemotherapy (FOLFOX)
Radiotherapy (rectal cancer)
Targeted therapy (EGFR inhibitors)