HEMATOLOGY
Etiology
• t(9;22) → BCR-ABL fusion (Philadelphia chromosome)
Pathogenesis
• Tyrosine kinase activation → ↑ mature granulocytes
Clinical features
• Fatigue, weight loss, night sweats
• Massive splenomegaly → early satiety
• May progress to blast crisis (AML/ALL)
Lab findings
• Marked leukocytosis (>100,000/µL)
• ↑ Basophils, eosinophils
• ↓ Leukocyte alkaline phosphatase (LAP)
• BCR-ABL positive
Treatment
• Imatinib (TKI)
• Stem cell transplant if resistant