HEMATOLOGY
Etiology
• EBV infection, genetic factors
Pathogenesis
• Reed–Sternberg cells (CD15⁺, CD30⁺) → cytokine release
Clinical features
• Painless lymphadenopathy (cervical, mediastinal)
• “B symptoms”: fever, night sweats, weight loss
• Alcohol-induced pain, pruritus
Lab findings
• RS cells on biopsy (“owl’s eye” nuclei)
• ↑ ESR, eosinophilia
• Mediastinal mass on imaging
Treatment
• ABVD chemotherapy
• Radiotherapy (localized)