DERMATOLOGY
Etiology
Autoimmune destruction of melanocytes
Associated with thyroid disease, diabetes, alopecia areata
Pathogenesis
CD8+ T-cell attack on melanocytes → depigmented patches
Clinical Features
Well-defined depigmented macules/patches
Symmetrical
Acral areas, face, around orifices
Wood’s lamp accentuates depigmentation
Treatment
Topical steroids or calcineurin inhibitors
Phototherapy (NB-UVB)
Cosmetic camouflage
JAK inhibitors (newer therapy)
Surgical grafts for stable cases