HEMATOLOGY
Etiology:
• X-linked enzyme deficiency
• Triggered by oxidative stress (drugs, fava beans, infection)
Pathogenesis:
• ↓ NADPH → RBC oxidative damage → hemolysis
Clinical Features:
• Jaundice, dark urine
• Pallor, fatigue
• Back pain
• Bite cells and Heinz bodies on smear
Treatment:
• Avoid oxidative triggers
• Supportive (hydration, transfusions if severe)