NEUROLOGY
Etiology
Autoimmune
Genetic susceptibility
Environmental factors (low vitamin D)
Pathogenesis
Immune-mediated demyelination of CNS
Formation of plaques → slowed nerve conduction
Clinical Features
Optic neuritis
Internuclear ophthalmoplegia
Sensory deficits
Lhermitte sign
Fatigue
Treatment
Acute relapse: IV steroids
Disease-modifying: interferon-β, glatiramer, natalizumab
Symptomatic: baclofen (spasticity), amantadine (fatigue)