Etiology

  • Gallstones

  • Alcohol

  • Hypertriglyceridemia

  • Drugs (thiazides, azathioprine)

Pathogenesis

  • Premature trypsin activation → pancreatic autodigestion → inflammation and necrosis

Diagnosis

  • ↑ Amylase, lipase

  • CT abdomen (if complications)

  • Ultrasound for gallstones

Treatment

  • Supportive: IV fluids, analgesia

  • Treat cause (ERCP for gallstones)

  • Nutritional support