Etiology

  • Chronic alcohol use

  • Genetic (CFTR, PRSS1)

  • Autoimmune

Pathogenesis

  • Repeated inflammation → fibrosis → loss of exocrine and endocrine function

Diagnosis

  • CT: calcifications

  • Fecal elastase ↓

  • Endoscopic ultrasound

Treatment

  • Pancreatic enzyme supplements

  • Analgesia

  • Control diabetes

  • Alcohol cessation