HEMATOLOGY
Etiology:
• Autoimmune marrow destruction, drugs (chloramphenicol), radiation
• Viral infections (parvovirus B19, hepatitis)
Pathogenesis:
• Bone marrow hypocellularity → pancytopenia
Clinical Features:
• Fatigue, pallor
• Infections (neutropenia)
• Petechiae, bleeding (thrombocytopenia)
• No splenomegaly
Treatment:
• Immunosuppressive therapy (ATG, cyclosporine)
• Bone marrow transplant